Delta E

DELTA E: INTEGRATORE DI VITAMINA E NATURALE

CONFEZIONE:
In vetro oscurato da 60 capsule

PRECAUZIONI D’UTILIZZO:
Questo integratore, essendo a base di Vitamina E naturale, non interferisce con nessun farmaco e non ha controindicazioni di alcun genere. Puo’ essere assunto anche dai bambini, dagli anziani e dalle donne in gravidanza.

INGREDIENTI PRINCIPALI:

• VITAMINA E NATURALE

INGREDIENTI:
capsula: gelatina alimentare; Acetato di D-alfa-tocoferile (vitamina E naturale); maltodestrine; antiagglomeranti: sali di magnesio degli acidi grassi.

Aggiornato al 25/10/2024

 

INTEGRATORI DI VITAMINA E: QUALI SONO I BENEFICI?

La vitamina E o tocoferolo esiste sotto diverse forme: ALFA, BETA, GAMMA e DELTA-tocoferolo. L’alfa tocoferolo è il più attivo.
E’ immagazzinato nel fegato e nei tessuti adiposi. Le principali fonti di vitamina E sono certamente gli oli vegetali che la vitamina E evita di far irrancidire (germe di grano, noce, girasole, cartamo, olive) mandorle e oli di pesce.

L’origine che Vita Complex ha scelto è di soia OGM FREE.

La vitamina E è una vitamina dalle proprietà multiple: interviene nel corretto funzionamento cellulare, interviene contro alcuni fattori ambientali (inquinamento dell’aria, raggi u.v., tabacco, radiazioni ionizzanti), i quali associati alla diminuzione progressiva degli enzimi dovuta all’invecchiamento (SOD e perioxidasi), portano alla produzione di radicali liberi e sovraccaricano le difese endogene. I radicali liberi portano ad un ossidazione degli acidi grassi polinsaturi.

La vitamina E limita questa aggressione preservando l’integrità delle membrane biologiche e delle lipoproteine.
Il D-alfatocoferolo è vitamina E naturale, ed è un grande antiossidante organico: protegge le membrane cellulare, gli occhi, l’apparato genitale e la pelle.

Questo ruolo antiossidante (2010;8 (10): 1) è fondamentale:

1- nella formazione delle placche di ateroma impedendo l’ossidazione del colesterolo LDL: quest’ultimo una volta ossidato si deposita sulle pareti dei vasi sanguigni provocando le malattie cardio-vascolari quali ipertensione, engina pectoris, infarto, ecc.

2- nell’attività delle piastrine: inibendo l’adesione delle piastrine, essa svolge un ruolo preventivo nei disordini della coagulazione con il rischio di trombosi, flebiti, embolie ecc.

3- nei fenomeni infiammatori delle malattie articolari o auto-immuni.

IMPORTANTE: il nostro organismo preferisce la vitamina E naturale: la vitamina E sintetica è meno cara, ma meno efficace, essa è due volte meno assorbita rispetto alla forma naturale e solamente il 12% della forma sintetica corrisponde all’isomero naturale, il solo utilizzato dall’organismo.

La vitamina naturale è diversa dalla vitamina sintetica come dimostra la diversità della formula.
Per fare un esempio la vitamina E nella forma naturale è chiamata RRR-ALFA TOCOFEROLO mentre la forma sintetica è denominata TOUT-RAC-ALFA TOCOFEROLO e consiste in un insieme di 8 molecole (stereoisomeri) tra le quali 7 non esistono in natura.

Le molecole sintetiche sono molto meno assimilate dall’organismo; esso inoltre ha difficoltà ad eliminare i residui di queste molecole sconosciute che possono divenire pertanto tossici.

Gli effetti protettori della vitamina E sono maggiorati dalla vitamina C, dalla vitamina A, dal selenio, dallo zinco e dal licopene.
E’ invece consigliato associarla alle vitamine B e acidi grassi polinsaturi nella regolazione delle difese immunitarie e in alcuni disordini ormonali (sfera genitale).

CONSIGLI DI UTILIZZO:
Si consiglia l’assunzione di una capsula al giorno.

Consigliamo inoltre le seguenti associazioni:

1- In inverno in prevenzione delle infezioni O.R.L. (raffreddore, rino-faringiti) compreso nei bambini per limitare le recidive: associare Delta E con Delta C Plus e Delta A.

2- Per le donne che prendono la pillola: associare la vitamina E con le vitamine B e A (Delta B, Delta A).

3- Per gli sportivi: associare la vitamina E con la vitamine C e B (Delta C Plus, Delta B).

4- Nelle malattie cardio-vascolari: in prevenzione e cura complementare dell’arteriosclerosi, l’angina, l’infarto, l’ictus: associare la vitamina E con Omega 3 e 9, il Ginkgo Biloba (Vitigin Complex da 200ml o 500ml).

Si può assumere la vitamina E durante o al di fuori dei pasti, ma è preferibile a fine pasto.

 

BASI SCIENTIFICHE – BIBLIOGRAFIA:

• Philippe Lagarde : Les vitamines – documentation scientifique SMC France 2007

• Philippe Lagarde : Guide d’utilisation des vitamines Edition Favre : 30-31 – 2000

• Philippe Lagarde: Vivere meglio e più a lungo M.i.r. edizioni 2009

• Wagner, Karl-Heinz; Afaf Kamal-Eldin, Ibrahim Elmadfa (2004). “Gamma-tocopherol–an underestimated vitamin?”. Annals of nutrition and metabolism 48 (3): 169–88. doi:10.1159/000079555. PMID 15256801. “In North America, the intake of γ-tocopherol has been estimated to exceed that of α-tocopherol by a factor of 2–4 … due to the fact that soybean oil is the predominant vegetable oil in the American diet (76.4%) followed by corn oil and canola oil (both 7%) … The supply of dietary fats … is much more diverse in Europe … The oils mainly consumed in Europe, i.e. sunflower, olive and canola oil, provide less γ-tocopherol but more α- tocopherol … [T]he ratio of α-:γ-tocopherol is at least 1:2. Therefore, the average γ-tocopherol intake can be estimated as 4–6 mg/day, which is about 25–35% of the USA intake. In accordance with the lower estimated European intake of γ-tocopherol, the serum levels of γ-tocopherol in European populations are 4–20 times lower than that of α-tocopherol”

• Jiang, Q; Christen, S; Shigenaga, MK; Ames, BN (2001). “gamma-tocopherol, the major form of vitamin E

in the US diet, deserves more attention”. The American journal of clinical nutrition 74 (6): 714–22.

PMID 11722951.

• Burton, G. W.; Ingold, K. U. (1981). “Autoxidation of biological molecules. 1. Antioxidant activity of vitamin E and related chain-breaking phenolic antioxidants in vitro”. J. Am. Chem. Soc. 103: 6472–6477. doi:10.1021/ja00411a035.

• US Food and Drug Administration: “Listing of Food Additives Status Part II”. Retrieved 2011-10-27.

• UK Food Standards Agency: “Current EU approved additives and their E Numbers”. Retrieved 2011-10- 27.

• Australia New Zealand Food Standards Code”Standard 1.2.4 – Labelling of ingredients”. Retrieved 2011- 10-27.

• Rigotti, A (2007). “Absorption, transport, and tissue delivery of vitamin E”. Molecular Aspects of Medicine 28 (5–6): 423–36. doi:10.1016/j.mam.2007.01.002. PMID 17320165.

• Jensen, S; Lauridsen, C (2007). “α‐Tocopherol Stereoisomers”. Vitamins & Hormones 76: 281–308. doi:10.1016/S0083-6729(07)76010-7. PMID 17628178.

• Brigelius-Flohé R, Traber MG (1 July 1999). “Vitamin E: function and metabolism”. FASEB J. 13 (10): 1145–55. PMID 10385606.

• Composition of Foods Raw, Processed, Prepared USDA National Nutrient Database for Standard Reference, Release 20 USDA, February 2008

• Sen, C; Khanna, S; Roy, S (2006). “Tocotrienols: Vitamin E beyond tocopherols”. Life Sciences 78 (18): 2088–98. doi:10.1016/j.lfs.2005.12.001. PMC 1790869. PMID 16458936.

• Evans, H. M.; Bishop, K. S. (1922). “On the Existence of a Hitherto Unrecognized Dietary Factor Essential for Reproduction”. Science 56 (1458): 650–651. doi:10.1126/science.56.1458.650. PMID 17838496.

• Evans H. M., Emerson O. H., Emerson G. A. (1 February 1936). “The isolation from wheat germ oil of an alcohol, a-tocopherol, having the properties of vitamin E”. Journal of Biological Chemistry 113 (1): 319–332.

• Fernholz, E. (1938). Journal of the American Chemical Society 60 (3): 700–705. doi:10.1021/ja01270a057.

• Iuliano, L.; Micheletta, F.; Maranghi, M.; Frati, G.; Diczfalusy, U.; Violi, F. (2001). “Bioavailability of Vitamin E as Function of Food Intake in Healthy Subjects: Effects on Plasma Peroxide-Scavenging Activity and Cholesterol-Oxidation Products”. Arteriosclerosis, Thrombosis, and Vascular Biology 21 (10): e34–e37. doi:10.1161/hq1001.098465.

• Vitamin E Fact sheet

• http://www.ars.usda.gov/SP2UserFiles/Place/12354500/

Data/SR22/nutrlist/sr22w323.pdf

• J. Bauernfeind in: L. J. Machlin (ed.): Vitamin E – A Comprehensive Treatise, Marcel Dekker, New York 1980, p. 99

• “USDA National Nutrient Database for Standard Reference”. USDA Agricultural Research Service. Retrieved 2009-11-26.

• Weiser H, Riss G, Kormann AW (1 October 1996). “Biodiscrimination of the eight alpha-tocopherol stereoisomers results in preferential accumulation of the four 2R forms in tissues and plasma of rats”. J. Nutr. 126 (10): 2539–49. PMID 8857515.

• “Taken together, these data indicate that of the eight stereoisomers (RRR, RSR, RRS, RSS, SRR, SSR, SRS, SSS) in all-rac-α-tocopherol, only the four 2R-forms (RRR, RSR, RSS, RRS) are recognized by α-TTP and maintained in the plasma. Indeed, the Food and Nutrition Board (Food and Nutrition Board and Institute of Medicine, 2000) has defined that only α-tocopherol, specifically the 2R-forms of α-tocopherol, can fulfill the human requirement for vitamin E. Thus, all-rac-α-tocopherol has only half the activity of RRR-α-tocopherol.”

Taken from the discussion in Lauridsen, C.; Engel, H.; Craig, AM.; Traber, MG. (Mar 2002). “Relative bioactivity of dietary RRR- and all-rac-alpha-tocopheryl acetates in swine assessed with deuterium-labeled vitamin E” (PDF). J Anim Sci 80 (3): 702–7. PMID 11890405.

• Mathias PM, Harries JT, Peters TJ, Muller DP (July 1981). “Studies on the in vivo absorption of micellar solutions of tocopherol and tocopheryl acetate in the rat: demonstration and partial characterization of a mucosal esterase localized to the endoplasmic reticulum of the enterocyte”. J. Lipid Res. 22 (5): 829–37. PMID 7288289.

• Ajandouz el H, Castan S, Jakob S, Puigserver A (2006). “A fast, sensitive HPLC method for the determination of esterase activity on alpha-tocopheryl acetate”. J Chromatogr Sci 44 (10): 631–3. PMID 17254374.

• Horwitt M, Elliott W, Kanjananggulpan P, Fitch C (1984). “Serum concentrations of alpha-tocopherol after

ingestion of various vitamin E preparations”. Am J Clin Nutr 40 (2): 240–5. PMID 6465056. link

• Cheeseman, K; Holley, A; Kelly, F; Wasil, M; Hughes, L; Burton, G (1995). “Biokinetics in humans of

RRR-α-tocopherol: The free phenol, acetate ester, and succinate ester forms of vitamin E”. Free Radical Biology and Medicine 19 (5): 591–8. doi:10.1016/0891-5849(95)00083-A. PMID 8529918.

• Burton, Graham W.; Ingold, Keith U.; Foster, David O.; Cheng, Shee C.; Webb, Ann; Hughes, Lise; Lusztyk, E (1988). “Comparison of free α-tocopherol and α-tocopheryl acetate as sources of vitamin E in rats and humans”. Lipids 23 (9): 834–40. doi:10.1007/BF02536201. PMID 3185118.

• Mathias PM, Harries JT, Muller DP (1 January 1981). “Optimization and validation of assays to estimate pancreatic esterase activity using well-characterized micellar solutions of cholesteryl oleate and tocopheryl acetate”. J. Lipid Res. 22 (1): 177–84. PMID 7217783.

• Taylor, H. R; Tikellis, G; Robman, LD; McCarty, CA; McNeil, JJ (2002). “Vitamin E supplementation and macular degeneration: randomised controlled trial”. BMJ 325 (7354): 11. doi:10.1136/bmj.325.7354.11. PMC 116664. PMID 12098721.

• Age-Related Eye Disease Study Research Group (2001). “A randomized, placebo-controlled, clinical trial

of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8”. Archives of ophthalmology 119 (10): 1417–36.

PMC 1462955. PMID 11594942.

• Van Leeuwen, R.; Boekhoorn, S; Vingerling, JR; Witteman, JC; Klaver, CC; Hofman, A; De Jong, PT (2005). “Dietary Intake of Antioxidants and Risk of Age-Related Macular Degeneration”. JAMA: the Journal of the American Medical Association 294 (24): 3101–7. doi:10.1001/jama.294.24.3101. PMID 16380590.

• Moriartycraige, S; Adkison, J; Lynn, M; Gensler, G; Bressler, S; Jones, D; Sternbergjr, P (2005). “Antioxidant Supplements Prevent Oxidation of Cysteine/Cystine Redox in Patients With Age-Related Macular Degeneration”. American Journal of Ophthalmology 140 (6): 1020–6. doi:10.1016/j.ajo.2005.06.043. PMID 16376645.

• Robertsii, L; Oates, J; Linton, M; Fazio, S; Meador, B; Gross, M; Shyr, Y; Morrow, J (2007). “The relationship between dose of vitamin E and suppression of oxidative stress in humans”. Free Radical Biology and Medicine 43 (10): 37–46. doi:10.1016/j.freeradbiomed.2007.06.019. PMC 2072864. PMID 17936185.

• Bjelakovic, G; Nikolova, D; Gluud, LL; Simonetti, RG; Gluud, C (2007). “Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis”. JAMA: the Journal of the American Medical Association 297 (8): 842–57. doi:10.1001/jama.297.8.842. PMID 17327526.

• Gaziano, JM (2004). “Vitamin E and cardiovascular disease: observational studies”. Annals of the New York Academy of Sciences 1031: 280–91. doi:10.1196/annals.1331.028. PMID 15753154.

• Frank, Bradford; Gupta, Sanjay (2005). “A Review of Antioxidants and Alzheimer’s Disease”. Annals of Clinical Psychiatry 17 (4): 269–86. doi:10.1080/10401230500296428. PMID 16402761.

• Ricciarelli, R; Argellati, F; Pronzato, M; Domenicotti, C (2007). “Vitamin E and neurodegenerative diseases”. Molecular Aspects of Medicine 28 (5–6): 591–606. doi:10.1016/j.mam.2007.01.004. PMID 17306357.

• Boothby, L. A; Doering, PL (2005). “Vitamin C and Vitamin E for Alzheimer’s Disease”. Annals of Pharmacotherapy 39 (12): 2073–80. doi:10.1345/aph.1E495. PMID 16227450.

• Helzlsouer, K. J.; Huang, HY; Alberg, AJ; Hoffman, S; Burke, A; Norkus, EP; Morris, JS; Comstock, GW (2000). “Association Between alpha-Tocopherol, gamma-Tocopherol, Selenium, and Subsequent Prostate Cancer”. Journal of the National Cancer Institute 92 (24): 2018–23. doi:10.1093/jnci/92.24.2018.

PMID 11121464.

• “The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers”. New England Journal of Medicine 330 (15): 1029–35. 1994. doi:10.1056/NEJM199404143301501. PMID 8127329.

• Cancer Research UK: Jury still out over vitamin E supplements and increased lung cancer risk

• Nursing in Practice – Vitamin E “linked to cancer”

• eCanadaNow.com – Vitamin E Linked To Increased Risk of Lung Cancer

• Jensen, SK; Lauridsen, C (2007). “Alpha-tocopherol stereoisomers”. Vitamins and hormones 76: 281– 308. doi:10.1016/S0083-6729(07)76010-7. PMID 17628178.

• Klein, EA (2004). “Selenium and vitamin E cancer prevention trial”. Annals of the New York Academy of Sciences 1031: 234–41. doi:10.1196/annals.1331.023. PMID 15753149.

• Slatore, C. G.; Littman, A. J.; Au, D. H.; Satia, J. A.; White, E. (2007). “Long-Term Use of Supplemental Multivitamins, Vitamin C, Vitamin E, and Folate Does Not Reduce the Risk of Lung Cancer”. American Journal of Respiratory and Critical Care Medicine 177 (5): 524–530. doi:10.1164/rccm.200709-1398OC. PMC 2258445. PMID 17989343.

• Age-Related Eye Disease Study Research Group (2001). “A randomized, placebo-controlled, clinical trial

of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. 9”. Archives of ophthalmology 119 (10): 1439–52. doi:10.1001/archopht.119.10.1439. PMC 1472812. PMID 11594943.

• McNeil, J; Robman, L; Tikellis, G; Sinclair, MI; McCarty, CA; Taylor, HR (2004). “Vitamin E supplementation and cataract*1Randomized controlled trial”. Ophthalmology 111 (1): 75–84. doi:10.1016/j.ophtha.2003.04.009. PMID 14711717.

• Engin, KN; Engin, G; Kucuksahin, H; Oncu, M; Engin, G; Guvener, B (2007). “Clinical evaluation of the

neuroprotective effect of alpha-tocopherol against glaucomatous damage”. European Journal of Ophthalmology 17 (4): 528–33. PMID 17671926.

• Sesso, H. D.; Buring, J. E.; Christen, W. G.; Kurth, T.; Belanger, C.; MacFadyen, J.; Bubes, V.; Manson, J. E. et al. (2008). “Vitamins E and C in the Prevention of Cardiovascular Disease in Men: The Physicians’ Health Study II Randomized Controlled Trial”. JAMA: the Journal of the American Medical Association 300 (18): 2123–2133. doi:10.1001/jama.2008.600. PMC 2586922. PMID 18997197.

• Vivekananthan, D; Penn, M; Sapp, S; Hsu, A; Topol, E (2003). “Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials”. The Lancet 361 (9374): 2017–23. doi:10.1016/S0140-6736(03)13637-9. PMID 12814711.

• Lonn, E; Bosch, J; Yusuf, S; Sheridan, P; Pogue, J; Arnold, JM; Ross, C; Arnold, A et al. (2005). “Effects of Long-term Vitamin E Supplementation on Cardiovascular Events and Cancer: A Randomized Controlled Trial”. JAMA: the Journal of the American Medical Association 293 (11): 1338–47. doi:10.1001/jama.293.11.1338. PMID 15769967.

• Huang, HY; Appel, LJ (2003). “Supplementation of diets with alpha-tocopherol reduces serum concentrations of gamma- and delta-tocopherol in humans”. The Journal of nutrition 133 (10): 3137–40.

PMID 14519797.

• Glynn, R. J.; Ridker, P. M; Goldhaber, S. Z.; Zee, R. Y.L.; Buring, J. E. (2007). “Effects of Random Allocation to Vitamin E Supplementation on the Occurrence of Venous Thromboembolism: Report From the Women’s Health Study”. Circulation 116 (13): 1497–1503. doi:10.1161/CIRCULATIONAHA.107.716407.

PMID 17846285.

• Etminan, Mahyar; Gill, Sudeep S; Samii, Ali (2005). “Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson’s disease: a meta-analysis”. The Lancet Neurology 4 (6): 362–5. doi:10.1016/S1474- 4422(05)70097-1.

• “Vitamin E cuts Parkinson’s risk”. BBC News. 19 May 2005. Retrieved 2008-01-01.

• Shoulson I (September 1998). “DATATOP: a decade of neuroprotective inquiry. Parkinson Study Group.

Deprenyl And Tocopherol Antioxidative Therapy Of Parkinsonism”. Ann. Neurol. 44 (3 Suppl 1): S160–6.

PMID 9749589.

• Rumbold, AR; Crowther, CA; Haslam, RR; Dekker, GA; Robinson, JS; Acts Study, Group (2006).

“Vitamins C and E and the risks of preeclampsia and perinatal complications”. The New England Journal of Medicine 354 (17): 1796–806. doi:10.1056/NEJMoa054186. PMID 16641396.

• Poston, L; Briley, AL; Seed, PT; Kelly, FJ; Shennan, AH (2006). “Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial”. The Lancet 367 (9517): 1145–54. doi:10.1016/S0140-6736(06)68433-X.

• Topical Vitamin E Formulations: Not Always Benign, Skin Therapy Letter Vol. 1, No. 3, January 1996

• Palmieri, Beniamino; Gozzi, Glauco; Palmieri, Gaspare (1995). “VITAMIN E ADDED SILICONE GEL

SHEETS FOR TREATMENT OF HYPERTROPHIC SCARS AND KELOIDS”. International Journal of Dermatology 34 (7): 506–9. doi:10.1111/j.1365-4362.1995.tb00628.x. PMID 7591421.

• O’Brien, Lisa; Pandit, Abhay; O’Brien, Lisa (2006). O’Brien, Lisa. ed. “Silicon gel sheeting for preventing and treating hypertrophic and keloid scars”. Cochrane database of systematic reviews (Online) (1): CD003826. doi:10.1002/14651858.CD003826.pub2. PMID 16437463.

• Baumann, Leslie S.; Md, James Spencer (1999). “The Effects of Topical Vitamin E on the Cosmetic Appearance of Scars”. Dermatologic Surgery 25 (4): 311–5. doi:10.1046/j.1524-4725.1999.08223.x. PMID 10417589. Lay summary – CosmeticsCop (2008-01-01)